反应详情

Prepared according to procedure B from 4-bromo-2-fluorophenylacetonitrile (T. Alessi A. H. P. U.S. Pat. No. 4,895,862) and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. A grey solid; mp 253-256° C. 1H-NMR(DMSO-d6) δ10.35 (s, 1H) 7.67-7.49 (m, 5H), 6.97 (d, 1H; J=8.6 Hz) 4.09 (s, 2H) 1.67 (s, 6H); MS [M−H]− m/z 309. Anal. Calc. For C18H15N2FO2.0.15H2O: C, 69.07; H, 4.93; N, 8.95. Found C, 69.27; H, 5.05; N, 8.50

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