5-Bromo-2-thiophenesulfonamide → HCID 69818761, compound

HRID 1882861Notes

Reaction equation

HRID 1882861 reaction equation
Br[C:2]1[S:6][C:5]([S:7]([NH2:10])(=[O:9])=[O:8])=[CH:4][CH:3]=1.[CH3:11][C:12]1([CH3:26])[C:17]2[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][C:16]=2[NH:15][C:14](=[O:25])[O:13]1>>[CH3:11][C:12]1([CH3:26])[O:13][C:14](=[O:25])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([C:4]3[CH:3]=[CH:2][S:6][C:5]=3[S:7]([NH2:10])(=[O:9])=[O:8])=[CH:18][C:17]1=2

Participants

3

Reactant 2

HCID 12413045-Bromo-2-thiophenesulfonamideHCID 10987806(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid

Product 1

HCID 69818761HCID 69818761, compound

Procedure

Prepared according to procedure B from 5-bromothiophene-2-sulphonamide and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. White solid: mp 258-260° C., 1H-NMR (DMSO-d6) δ10.41 (s, 1H), 7.71 (s, 2H), 7.58 (m, 2H), 7.52 (d, 1H, J=3.9 Hz), 7.48 (d, 1H J=8.16 Hz), 6.95(d, 1H J=8.16), 1.66 (s, 6H); MS m/z 337 (M−H). Anal. Calc. For C14H14N2O4S2: C, 49.69; H, 4.17; N, 8.28. Found: C, 49.90; H, 4.28; N, 8.12.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e12af5493ca7412295c771003052078b
Source dataset
uspto-grants-2004_07
Patent number
US06759408B2

Reaction notes

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