反应详情

The desired compound was prepared by the method of Example 8 from 300 mg (2.11 mmol) of 1-methyl-piperidin-3-carbaldehyde oxime prepared in Example 5 and 528 mg (2 equivalents) of 1-allyl pyrrolidin-2-one prepared in Example 6 and purified by separation with silica gel column chromatography using chloroform/methanol (gradient of 20:1 to 10:1) as eluent to obtain 230.1 mg (41% yield) of 1-[3-(1-methyl-piperidin-3-yl)-4,5-dihydro-isoxazol-5-yl-methyl]-pyrrolidin-2-one. Subsequently, 1:1 acid addition salt with oxalic acid was obtained from the diethyl ether solution.

1. custompurified by separation with silica gel column chromatography