HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridine aldoxime → HCID 23509808, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridine aldoxime | HCID 694 | — |
| Reactant | 1-(Prop-2-yn-1-yl)pyrrolidin-2-one | HCID 12464313 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | HCID 23509808 | HCID 23509808 | 35.4% |
Reaction Steps
The desired compound was prepared by the method of Example 8 from 500 mg (4.09 mmol) of 3-pyridine aldoxime and 1.0 g (2 equivalents) of 1-propargyl pyrrolidin-2-one prepared in Example 7, and purified by separation with silica gel column chromatography using ethyl acetate and then chloroform/methanol (30:1) to obtain 352.2 mg (35.4% yield) of 1-(3-pyridin-3-yl-isoxazol-5-yl-methyl)-pyrrolidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759419B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-1f8b9e7d113343a6a18caec67aba3f20 |
| Source note | uspto-grants-2004_07 |