HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 23510024, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2-[4-(Methoxycarbonyl)phenyl]-1H-benzimidazole-6-carboxylic acid | HCID 16084359 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23510024 | HCID 23510024 | — |
Reaction Steps
A mixture of 2-(4-methoxycarbonyl-phenyl)-3H-benzoimidazole-5-carboxylic acid (5.0 g) in DMF (250 mL) and CDI (7.1 g) was stirred at RT for 3.0 hours and then treated with cyclohexyl amine (2.0 g) and refluxed for 96 hours. The reaction mixture was cooled and then poured into water (2.0 L) and stirred at RT for 16 hours. The product was filtered, washed with water and ether and then recrystallized from THF, methanol and ether. Yield 0.4 g. TLC one spot (9:1)-CH2Cl2—CH3OH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759425B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-7013dfd498794b31b34643516c1d0a7c |
| Source note | uspto-grants-2004_07 |