Potassium → HCID 56984651, compound

HRID 1882913Notes

Reaction equation

HRID 1882913 reaction equation
C([O:4][C@H:5]1[CH2:29][CH2:28][C@@:27]2([CH3:30])[C@@H:7]([C@@H:8]([OH:32])[CH2:9][C:10]3[C@H:11]4[C@:23]([CH3:31])([CH2:24][CH2:25][C:26]=32)[C@@H:14]([C@H:15]([CH3:22])[CH2:16][CH2:17][CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:13][CH2:12]4)[CH2:6]1)(=O)C.[K]>C(O)C>[CH3:21][CH:19]([CH2:18][CH2:17][CH2:16][C@H:15]([C@@H:14]1[C@:23]2([CH3:31])[C@H:11]([C:10]3[CH2:9][C@@H:8]([OH:32])[C@H:7]4[C@:27]([C:26]=3[CH2:25][CH2:24]2)([CH3:30])[CH2:28][CH2:29][C@H:5]([OH:4])[CH2:6]4)[CH2:12][CH2:13]1)[CH3:22])[CH3:20]

Participants

4

Reactant 2

HCID 5462222PotassiumHCID 69763044HCID 69763044, compound

Product 1

HCID 56984651HCID 56984651, compoundYield 85.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3β-(Acetyloxy)-5α-cholest-8-ene-6α-ol (124 mg) is dissolved in 20 ml ethanol. Solid potassium hydroxyde (710 mg) is added and the reaction mixture is stirred for 2 hours. After aqueous work-up, 5β-cholest-8-ene-3β,6β-diol (96 mg) is isolated.

Sources & evidence

ORD record
ord-da7a7318b9974475bb6760937fa4a3e2
Source dataset
uspto-grants-2004_07
Patent number
US06759400B2

Reaction notes

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