Cyclopropanecarboxaldehyde → HCID 69876205, compound

HRID 1882932Notes

Reaction equation

HRID 1882932 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:29])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([CH:19]2[CH2:24][CH2:23][N:22](CC3CC3)[CH2:21][CH2:20]2)=[O:18])=[N:6][CH:7]=1.F[C:31](F)(F)C(O)=O.ClC1C=CC(N[C:45](=O)[C:46]2[CH:51]=CC=CC=2NC(C2CCNCC2)=O)=NC=1.C1(C=O)CC1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:29])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([CH:19]2[CH2:24][CH2:23][N:22]([CH:51]3[CH2:46][CH2:45]3)[CH:21]([CH3:31])[CH2:20]2)=[O:18])=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 123114CyclopropanecarboxaldehydeHCID 21906185HCID 21906185, compoundHCID 21906487HCID 21906487, compound

Product 1

HCID 69876205HCID 69876205, compound

Procedure

Using procedures substantially equivalent to those described in example 9-C, N-(5-chloropyridin-2-yl)-2-[(1-cyclopropylmethylpiperidin-4-ylcarbonyl)amino]benzamide (16 mg, 72%, 97% pure by HPLC analysis) was prepared from N-(5-chloropyridin-2-yl)-2-[(piperidin-4-ylcarbonyl)amino]-benzamide trifluoroacetate and cyclopropanecarboxaldehyde.

Sources & evidence

ORD record
ord-e46d318cc11e402e9b49820e406135af
Source dataset
uspto-grants-2004_07
Patent number
US06759414B2

Reaction notes

Loading…