Trifluoroacetate → HCID 9935845, compound

HRID 1882967Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:34])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([O:19][CH:20]([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)C(OC(C)(C)C)=O)=[O:18])=[N:6][CH:7]=1.[F:35][C:36]([F:41])([F:40])[C:37]([O-:39])=[O:38]>>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:34])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([O:19][CH2:20][CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[O:18])=[N:6][CH:7]=1

Participants

Reactant 2

HCID 84468Trifluoroacetate

HCID 69666485HCID 69666485, compound

Product 1

HCID 9935845HCID 9935845, compoundYield 99%

Procedure

Using a similar procedure to that described in Example 9-B, N-(5-chloropyridin-2-yl)-2-[(1-tert-butoxycarbonyl-piperidin-4-ylmethoxycarbonyl)amino]benzamide (300 mg, 0.615 mmol) yielded 308 mg (99%) of the title compound as a trifluoroacetate salt.

Sources & evidence

ORD record: ord-66a7ea9c4a3a4196be6fcc0ae63f278c
Source dataset: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06759414B2

Reaction notes

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