Trifluoroacetate → HCID 69667646, compound

HRID 1882968Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:33])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([O:19][CH:20]2[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]2)=[O:18])=[N:6][CH:7]=1.[F:34][C:35]([F:40])([F:39])[C:36]([O-:38])=[O:37]>>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:33])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([O:19][CH:20]2[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2)=[O:18])=[N:6][CH:7]=1

Participants

Reactant 2

HCID 84468Trifluoroacetate

HCID 21906200HCID 21906200, compound

Product 1

HCID 69667646HCID 69667646, compoundYield 99%

Procedure

Using a similar procedure to that described in Example 9-B, N-(5-chloropyridin-2-yl)-2-[(1-tert-butoxycarbonylpiperidin-4-yloxycarbonyl)amino]benzamide (1.90 g, 4.00 mmol) yielded 1.95 g (99%) of the titled compound as a trifluoroacetate salt.

Sources & evidence

ORD record: ord-0f2f86b2379445a4a61f5ec2d4558544
Source dataset: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06759414B2

Reaction notes

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