HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-formylpiperidine-1-carboxylate → N-(5-Chloropyridin-2-yl)-4-methoxycarbonyl-2-(piperidin-4-ylmethylamino)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-formylpiperidine-1-carboxylate | HCID 1514430 | — |
| Reactant | Borane,N-dimethylmethanamine (1:1) | HCID 6327651 | — |
| Reactant | 2-amino-N-(5-chloropyridin-2-yl)-4-methoxycarbonylbenzamide | HCID 21906318 | — |
| Product | N-(5-Chloropyridin-2-yl)-4-methoxycarbonyl-2-(piperidin-4-ylmethylamino)benzamide | HCID 21906188 | 84% |
Reaction Steps
Using a similar procedure to that described in Example 47-C&D, 2-amino-N-(5-chloropyridin-2-yl)-4-methoxycarbonylbenzamide (1.00 g, 3.28 mmol), 1-tert-butoxycarbonyl-piperidine-4-carboxaldehyde (1.05 g, 4.92 mmol), and borane trimethylamine complex (717 mg, 9.94 mmol) afforded 1.10 g (84%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759414B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-ab777cd1572e4d30a325d40bad5eeb79 |
| Source note | uspto-grants-2004_07 |