HCID 21906365, compound → HCID 21906584, compound

HRID 1883036Notes

Reaction equation

HRID 1883036 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(N)(=O)C1C=CC=CC=1.C(OC([N:24]1[CH2:29][CH2:28][CH:27]([C:30]([NH:32][C:33]2[CH:48]=[C:47]([Cl:49])[CH:46]=[CH:45][C:34]=2[C:35]([NH:37][C:38]2[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][N:39]=2)=[O:36])=[O:31])[CH2:26][CH2:25]1)=O)(C)(C)C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:49][C:47]1[CH:46]=[CH:45][C:34]([C:35]([NH:37][C:38]2[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][N:39]=2)=[O:36])=[C:33]([NH:32][C:30]([CH:27]2[CH2:28][CH2:29][NH:24][CH2:25][CH2:26]2)=[O:31])[CH:48]=1

Participants

3

Reactant 2

HCID 21906365HCID 21906365, compoundHCID 22629487HCID 22629487, compound

Product 1

HCID 21906584HCID 21906584, compound

Procedure

Using methods substantially equivalent to those described in Example 9-B, 4-chloro-N-(5-chloropyridin-2-yl)-2-1(4-piperidinylcarbonyl)amino]benzamide trifluoroacetate (3.66 g, 93%) was prepared from 2-[(1-tert-butoxycarbonylpiperidin-4-ylcarbonyl)amino]-4-chloro-N-(5-chloropyridin-2-yl)benzamide.

Sources & evidence

ORD record
ord-8a4f67ee6cff4db5b72af71ed08a5c3d
Source dataset
uspto-grants-2004_07
Patent number
US06759414B2

Reaction notes

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