Formaldehyde → HCID 21906363, compound

HRID 1883060Notes

Reaction equation

HRID 1883060 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:30])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][CH2:17][CH:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)[CH2:20][CH2:19]2)=[N:6][CH:7]=1.[CH2:31]=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:30])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N:16]([CH3:31])[CH2:17][CH:18]2[CH2:19][CH2:20][N:21]([C:24]3[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=3)[CH2:22][CH2:23]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 21906313HCID 21906313, compound

Product 1

HCID 21906363HCID 21906363, compound

Procedure

Using a similar procedure to that described in Example 27, N-(5-chloropyridin-2-yl)-2-[1-(4-pyridinyl)piperidin-4-ylmethyl]aminobenzamide (100 mg, 0.237 mmol) and paraformaldehyde (20 mg, 0.238 mmol) afforded, after purification by column chromatography (SiO2: 2 to 4% [2 N ammonia in methanol]:chloroform), 25 mg (24%) of the title compound.

Workup

  1. customafforded
  2. customafter purification by column chromatography (SiO2: 2 to 4% [2 N ammonia in methanol]:chloroform), 25 mg (24%) of the title compound

Sources & evidence

ORD record
ord-74c84985b263403989d6bcdbb38bc2bb
Source dataset
uspto-grants-2004_07
Patent number
US06759414B2

Reaction notes

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