HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane,N-dimethylmethanamine (1:1) → HCID 21906491, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane,N-dimethylmethanamine (1:1) | HCID 6327651 | — |
| Reactant | N-(5-chloropyridin-2-yl)-4-hydroxymethyl-2-[(1-Boc-piperidin-4-ylmethyl)amino]benzamide | HCID 21906512 | — |
| Product | HCID 21906491 | HCID 21906491 | 79% |
Reaction Steps
Using a similar procedure to that described in Example 47-D, N-(5-chloropyridin-2-yl)-4-hydroxymethyl-2-[(1-Boc-piperidin-4-ylmethyl)amino]benzamide (1.45 g, 3.07 mmol) and borane trimethylamine complex (672 mg, 9.22mmol) afforded 900 mg (79%) of the title compound, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759414B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-77cc94acadc3412d85db7671c82aadee |
| Source note | uspto-grants-2004_07 |