tert-Butyl 4-formylpiperidine-1-carboxylate → HCID 21906567, compound

Participants

Reaction Steps

Using a similar procedure to that described in Example 47-C&D, 2-amino-N-(5-chloropyridin-2-yl)-5-methoxycarbonylbenzamide (3.23 g, 10.6 mmol), 1-tert-butoxycarbonylpiperidine-4-carboxaldehyde (2.50 g, 11.7 mmol), and borane trimethylamine complex (2.31 g, 31.7 mmol) afforded, after purification by column chromatography (SiO2: 10 to 25% methanol:methylene chloride), 3.10 g (73%) of the title compound.

Provenance & Evidence