HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → (S)-tert-Butyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | tert-Butyl (2S)-benzyloxycarbonylamino-3-tert-butoxycarbonylaminopropionate | HCID 53876012 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | (S)-tert-Butyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate hydrochloride | HCID 86585733 | 99% |
Reaction Steps
13.1 g of tert-butyl (S)-2-benzyloxycarbonylamino-3-tert-butoxycarbonylaminopropionate were hydrogenated over 10% Pd/C in methanol/HCl. After 1.5 h, the mixture was filtered and the filtrate was concentrated in vacuo. 9.77 g (99%) of tert-butyl (S)-2-amino-3-tert-butoxycarbonylaminopropionate hydrochloride were obtained as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759424B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-66365f2b6fb347eebe7b880b6e5410b9 |
| Source note | uspto-grants-2004_07 |