反应详情

1.9 g (3.59 mmol) of 169.3 in 190 ml of ethanol were hydrogenated over 76 mg of 10% palladium/carbon for 2 h. The catalyst was filtered off, the solvent was removed in vacuo, the residue was dissolved in ethyl acetate and the solution was washed with a 10% strength sodium hydrogen carbonate solution. The phases were separated and the organic phase was dried over sodium sulfate. After filtration, 1.3 g (80%) of 169.4 were obtained.

1. filtrationThe catalyst was filtered off
2. customthe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in ethyl acetate
4. washthe solution was washed with a 10% strength sodium hydrogen carbonate solution
5. customThe phases were separated
6. dry with materialthe organic phase was dried over sodium sulfate
7. filtrationAfter filtration