Trifluoroacetic acid → (s)-3-((s)-2-((s)-4-Phenyl-3-benzyl-4-methyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(2,4-dimethoxyphenyl)propionic acid

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	Tert-butyl (s)-3-amino-3-(2,4-dimethoxyphenyl)propionate	HCID 53676007	—
Reactant	(s)-2-((s)-4-Phenyl-3-benzyl-4-methyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetate	HCID 131723411	—
Product	(s)-3-((s)-2-((s)-4-Phenyl-3-benzyl-4-methyl-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(2,4-dimethoxyphenyl)propionic acid	HCID 59902382	—

Reaction Steps

(by reaction of 169.5 with tert-butyl (S)-3-amino-3-(2,4-dimethoxyphenyl)propionate and subsequent cleavage of the tert-butyl ester with trifluoroacetic acid)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06759424B2
Source dataset	uspto-grants-2004_07
ORD ID	ord-240ca2e711454e47b0c32d132506c37b
Source note	uspto-grants-2004_07