Lithium Hydroxide → HCID 23510277, compound

Participants

Reaction Steps

To 134 mg (0.465 mmol) of ethyl 6{[(allyloxy)carbonyl]amino}-1H-indole-2-carboxylate dissolved in 5 mL methanol was added 43 mg (1.023 mmol) lithium hydroxide dissolved in 1 mL water. The mixture was stirred at room temperature overnight, partitioned between ethyl acetate and 1 N HCl until neutral, dried over magnesium sulfate and concentrated to provide 118 mg 6-{[(allyloxy)carbonyl]amino}-1H-indole-2-carboxylic acid, as a colorless solid.

Provenance & Evidence