Lithium Hydroxide → HCID 23510084, compound

Participants

Reaction Steps

To 333 mg (1.24 mmol) of methyl 6-[(methylsulfonyl)amino]-1H-indole-2-carboxylate dissolved in 8 mL methanol was added 130 mg (3.10 mmol) lithium hydroxide dissolved in 2 mL water. The mixture was stirred at room temperature overnight, partitioned between ethyl acetate and 1 N hydrochloric acid, was dried over magnesium sulfate and concentrated to obtain 230 mg of 6-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid.

Provenance & Evidence