HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 23510209, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Ethyl 6-methyl-1H-indole-2-carboxylate | HCID 19927845 | — |
| Reactant | HCID 60083619 | HCID 60083619 | — |
| Reactant | HCID 60083687 | HCID 60083687 | — |
| Product | HCID 23510209 | HCID 23510209 | — |
Reaction Steps
Similarly, using pyrazole and 1-methyl-piperazine respectively in place of imidazole in reaction with 6-methyl-1H-indole-2-carboxylic acid ethyl ester, the compounds 6-pyrazol-1-ylmethyl-1H-indole-2-carboxylic acid and 6-(4-methyl-piperazin)-1-ylmethyl-1H-indole-2-carboxylic acid were prepared. These acids in turn were used to make 6-pyrazol-1-ylmethyl-1H-indole-2-carboxylic acid [(1S,2R)-2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide and 6-(4-methyl-piperazin-1-ylmethyl)-1H-indole-2-carboxylic acid [(1S,2R)-2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide using the coupling procedure of Example 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759428B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-a93caa8db20b4561b248e376d6da65d0 |
| Source note | uspto-grants-2004_07 |