HCID 23510044, compound → HCID 20740222, compound

HRID 1883125Notes

Reaction equation

HRID 1883125 reaction equation
Br.[NH2:2][CH:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)[C:4]#[N:5].[CH3:12][N:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[C:14]1[C:22]([NH:24][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH:26]1[C:31](O)=[O:32])=[O:23]>>[C:4]([CH:3]([NH:2][C:31]([C@@H:26]1[CH2:27][CH2:28][CH2:29][CH2:30][C@@H:25]1[NH:24][C:22]([C:14]1[N:13]([CH3:12])[C:21]2[C:16]([CH:15]=1)=[CH:17][CH:18]=[CH:19][CH:20]=2)=[O:23])=[O:32])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)#[N:5]

Participants

3

Reactant 2

HCID 23510044HCID 23510044, compoundHCID 23510299HCID 23510299, compound

Product 1

HCID 20740222HCID 20740222, compound

Procedure

Amino-pyridin-2-yl-acetonitrile hydrobromide and 2-[(1-Methyl-1H-indole-2-carbonyl)-amino]-cyclohexanecarboxylic acid were coupled as described in Example 1 to provide methyl-1H-indole-2-carboxylic acid {(1S,2R)-2-[(cyano-pyridin-2-yl-methyl)-carbamoyl]-cyclohexyl}-amide.

Sources & evidence

ORD record
ord-2865dad1d76844f7808ea791c05cf4ef
Source dataset
uspto-grants-2004_07
Patent number
US06759428B2

Reaction notes

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