Tetrahydrofuran → HCID 20740230, compound

Participants

Reaction Steps

To a solution of 1-methyl-1H-indole-2-carboxylic acid [((1S,2R)-2-((S)-1-cyano-3-methylsulfanyl-propylcarbamoyl)-cyclohexyl]-amide (compound 3-2, 203 mg, 0.492 mmol) in 20 mL of THF, was added Oxone™ (390 mg, 0.634 mmol). The reaction mixture was stirred at ambient temperature for 2 hours, filtered through a pad of celite, dried with sodium sulfate, filtered, concentrated, and purified by column chromatography (5:95, MeOH/CH2Cl2) to give 178 mg (81%) of 1-methyl-1H-indole-2-carboxylic acid [(1S,2R)-2-((S)-1-cyano-3-methanesulfonyl-propylcarbamoyl)-cyclohexyl]-amide as a yellow amorphous solid. MS: 445 (M+H+).

Provenance & Evidence