Hydrochloric Acid → HCID 23510200, compound

Participants

Reaction Steps

To a solution of ethanol (20 mL), water (0.08 mL, 4 mmol), hydrogen chloride (10.8 mL, 1M in diethylether) was added a solution of 2-(benzhydrylidene-amino)-3-(2-chloro-pyridin-4-yl)-propionitrile (1.50 g, 4 mmol) in ethanol (15 mL) and methanol (5 mL). The reaction was stirred for 20 minutes, then concentrated to one third volume. The crude residue was triturated with hexane (20 mL), ethanol (10 mL), three 30 mL portions of hexane:ether (4:1 vol:vol) and three 30 mL portions of hexane. The precipitate was dried in vacuo to give 2-amino-3-(2-chloro-pyridin-4-yl)-propionitrile as an off white powder (0.90 g, 82%).

Provenance & Evidence