HCID 23510279, compound → HCID 60083651, compound

HRID 1883152Notes

Reaction equation

HRID 1883152 reaction equation
[C:1]([C@@H:3]([NH:8][C:9]([C@@H:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C@@H:12]1[NH2:17])=[O:10])[CH2:4][CH:5]([CH3:7])[CH3:6])#[N:2].[Cl:18][CH2:19][CH2:20][CH2:21][N:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[C:23]1[C:31](O)=[O:32]>>[C:1]([C@@H:3]([NH:8][C:9]([C@@H:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C@@H:12]1[NH:17][C:31]([C:23]1[N:22]([CH2:21][CH2:20][CH2:19][Cl:18])[C:30]2[C:25]([CH:24]=1)=[CH:26][CH:27]=[CH:28][CH:29]=2)=[O:32])=[O:10])[CH2:4][CH:5]([CH3:7])[CH3:6])#[N:2]

Participants

3

Reactant 2

HCID 23510279HCID 23510279, compoundHCID 60091040HCID 60091040, compound

Product 1

HCID 60083651HCID 60083651, compound

Procedure

(1R,2S)-2-Amino-cyclohexanecarboxylic acid ((S)-1-cyano-3-methyl-butyl)-amide was coupled with afford 1-(3-chloro-propyl)-1H-indole-2-carboxylic acid using the procedure of Example 11 to yield 1-(3-chloro-propyl)-1H-indole-2-carboxylic acid [(1S,2R)-2-((S)-1-cyano-3-methyl-butylcarbamoyl)-cyclohexyl]-amide.

Sources & evidence

ORD record
ord-562c9de994544e6b8feff694d9ec42ec
Source dataset
uspto-grants-2004_07
Patent number
US06759428B2

Reaction notes

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