Acetic Acid → HCID 20740234, compound

Participants

Reaction Steps

To 120 mg (0.25 mmol) of 1-methyl-1H-indole-2-carboxylic acid ((1S,2R)-2-{[(S)-cyano-(4-nitro-benzyl)-methyl]-carbamoyl}-cyclohexyl)-amide dissolved in 5 mL ethyl acetate was added 20 mg activated carbon on charcoal (10% Wt.) and 0.7 mL glacial acetic acid. The reaction mixture was hydrogenated under normal atmosphere (H2 balloon) for two hours, filtered through a cake of celite, washed with water and 10% NaOH aqueous solution, dried over magnesium sulfate, and concentrated to provide 80 mg of 1-methyl-1H-indole-2-carboxylic acid ((1S,2R)-2-{[(S)-(4-amino-benzyl)-cyano-methyl]-carbamoyl}-cyclohexyl)-amide. HPLC: 92% pure, yield: 71%, MS: 444 (M+H+).

Provenance & Evidence