Tetrabutylammonium Fluoride → HCID 60083609, compound

Participants

Reaction Steps

Proceeding as described in Example 11, followed by treatment with 1M TBAF in THF at 50° C. for 12 h, 1-(2-Methyl-2-triisopropylsilanyloxy-propyl)-1H-indole-2-carboxylic acid (100 mg, 0.25 mmol) was concerted to 1-(2-hydroxy-2-methyl-propyl)-1H-indole-2-carboxylic acid [2-(1-cyano-3-methyl-butylcarbamoyl)-cyclohexyl]-amide (80 mg; SiO2 PTLC: 50% ethyl acetate/hexanes; mp: 101.5-105.5° C.; MS: M+H=453).

Provenance & Evidence