tert-Butyl 4-(3-bromopropyl)piperidine-1-carboxylate → HCID 20740364, compound

Participants

Reaction Steps

Proceeding as described in Example 54, Step 3, 673 mg of 4-(3-bromo-propyl)-piperidine-1-carboxylic acid tert-butyl ester (2.2 mmol) was conyerted to approximately 180 mg 1-(3-Piperidin-4-yl-propyl)-1H-indole-2-carboxylic acid [2-(1-cyano-3-methyl-butylcarbamoyl)-cyclohexyl]-amide, hydrochloride salt (MS: M+H=506; mp=146.4-146.9 C).

Provenance & Evidence