反应详情

To a solution of 3-nitro-1,2-phenylenediamine (2.67 g) and a 2N KOH (8.7 mL) in ethanol (250 mL) was added a 40% aqueous solution of pyruvic aldehyde (17.72 g) at 60° C. The mixture was heated under reflux for 10 minutes, and thereto was added water (150 mL). The mixture was cooled to room temperature, and concentrated under reduced pressure. The precipitated crystals were collected by filtration, washed with cold water, and dried under reduced pressure to give 2-methyl-5-nitroquinoxaline (2.21 g, 67%) as pale brown solid.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 10 minutes
3. concentrationconcentrated under reduced pressure
4. filtrationThe precipitated crystals were collected by filtration
5. washwashed with cold water
6. customdried under reduced pressure