Bromine → HCID 23510323, compound

HRID 1883187Notes

Reaction equation

HRID 1883187 reaction equation
[CH3:1][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH2:12])[CH:8]=2)[N:3]=1.[Br:13]Br>C(O)(=O)C>[BrH:13].[CH3:1][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH2:12])[C:8]=2[Br:13])[N:3]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 126667146-Quinoxalinamine,2-methyl-(9CI)

Product 1

HCID 23510323HCID 23510323, compoundYield 188.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of 2-methyl-6-aminoquinoxaline (15.8 g) in acetic acid (150 mL) was added dropwise a solution of bromine (15.88 g) in acetic acid (11 mL) at 0° C. After the addition, the reaction solution was stirred at 0° C. for one hour, and the precipitates were collected by filtration, washed with ether, and dried to give 2-methyl-6-amino-5-bromoquinoxaline hydrobromide (29.86 g, 94%), which was neutralized to give 2-methyl-6-amino-5-bromoquinoxaline.

Workup

  1. additionAfter the addition
  2. filtrationthe precipitates were collected by filtration
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-a296f89623b748929b86ef756e4ab513
Source dataset
uspto-grants-2004_07
Patent number
US06759429B2

Reaction notes

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