HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → Methyl 2-amino-5-chlorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-5-chlorobenzoic acid | HCID 12476 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Methyl 2-amino-5-chlorobenzoate | HCID 78878 | 96.1% |
Reaction Steps
5-Chloroanthranilic acid (15.0 g), (CH3)2SO4 (11.6 g) and K2CO3 (12.7 g) were refluxed in acetone (150 g) for 30 minutes. The mixture was concentrated to about 90 g, and thereto was added water (90 g). The mixture was extracted with toluene (75 g), and the organic layer was concentrated to give methyl 5-chloroanthranilate (15.6 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759429B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-a45c73a01c664c67a5a90c12b5c4893f |
| Source note | uspto-grants-2004_07 |