Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Morpholinobenzonitrile | HCID 394808 | 65.4% |
Reaction Steps
Under nitrogen atmosphere, to a solution of 4-fluorobenzonitrile (24.9 g) in CH3CN (500 mL) was added morpholine (53.8 g), and the mixture was stirred at 82° C. for 50 hours. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column (hexane/ethyl acetate=10/1→4/1) to give 4-morpholin-4-yl-benzonitrile (25.3 g, 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06759429B2 |
|---|
| Source dataset | uspto-grants-2004_07 |
|---|
| ORD ID | ord-539cc28bb2aa4d87927abd65ae448381 |
|---|
| Source note | uspto-grants-2004_07 |
|---|
