Hydrochloric Acid → HCID 85074544, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 7-(3,5-diisopropyl-2-propoxy-phenyl)-3-methyl-nona-2,4,6-trienoic acid ethyl ester (Compound 7, 11.4 g, 27.7 mmol) in EtOH (220 mL) was treated with 1M NaOH (111 mL, 111 mmol) and was heated to 80 ° C. for 3 h. The mixture was cooled to room temperature, acidified with 1M HCl (115 mL), and was extracted with EtOAc. The organic layer was separated, washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by recrystallization from CH3CN to yield the title compound as an off-white solid (7.56 g, 71%).

Provenance & Evidence