HCID 10890148, compound → HCID 69869174, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6,8-diisopropyl-4-methylchromen-2-one Intermediate 11, 2.6 g, 10.7 mmol) in Et2O (100 mL) at 0° C. was added LiAlH4 portionwise (405 mg, 10.7 mmol). The reaction was stirred at 0° C. for 1 h, quenched by careful addition of ice, and acidified with 1M HCl. The mixture was then extracted with EtOAc. The organic layer was separated, washed successively with H2O, brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (20% EtOAc-hexanes) to yield the title compound as a nearly colorless syrup (1.82 g, 70%).

Provenance & Evidence