Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Iminodiacetic acid | HCID 8897 | — |
| Reactant | Acetylglycine | HCID 10972 | — |
| Reactant | HCID 23599706 | HCID 23599706 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-acetyliminodiacetic acid | HCID 10130190 | 95% |
Reaction Steps
A 300 mL autoclave was charged with acetamide (VII)(11.8 g, 0.2 mole), 95% paraformaldehyde (13.6 g, 0.43 mole), water (12.9 g, 0.72 mole), acetic acid (2.1 g, 0.035 mole), acetone (90 mL) and Co2(CO)8 (2.1 g, 0.006 mol) and pressurized to 3200 psi (22,069 kPa) CO:H2 (95:5) at 25° C. This mixture was heated to 110° C. for 30 min. HPLC analysis of this stream indicated a 95% yield of (XVI), 0.5% (XIV), and 4.5% (XVIII).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06759549B2 |
|---|
| Source dataset | uspto-grants-2004_07 |
|---|
| ORD ID | ord-c1c83f7af0f944f59a89c16a4ab924ad |
|---|
| Source note | uspto-grants-2004_07 |
|---|
