HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-methyl-N-(phosphonomethyl)glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Phosphorous acid | HCID 107909 | — |
| Reactant | N-Acetyl-N-methylglycine | HCID 10975514 | — |
| Product | N-methyl-N-(phosphonomethyl)glycine | HCID 541499 | 99% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
N-acetyl sarcosine (XX) (20.0 g, 152.5 mmole), phosphorous acid (12.59, 152.4 mmole), and concentrated HCl (37.6 g) were mixed and refluxed in a 120° C. oil bath. Formalin, 37% (13.6 g, 167.6 mmole) was added dropwise over 20 min. and the reaction was continued for an additional 19 h. HPLC analysis indicated a-99% yield of N-methylglyphosate (XXI) based on moles of (XX) charged.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759549B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-3d95f3a6fd50403fb5bdf571eec7565c |
| Source note | uspto-grants-2004_07 |