Sodium Hydroxide → HCID 9824133, compound

Participants

Reaction Steps

Following General Procedure E and using (2Z,4E,6E)-7-(-3-ethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-2,6-difluoro-3-methyl-nona-2,4,6-trienoic acid ethyl ester (Compound 25, 81 mg, 0.18 mmol), 1M NaOH (0.53 mL), and EtOH (2 mL) at 40° C. for overnight followed by flash column chromatography on silica gel (10%→50% EtOAc-hexane), the title compound was obtained as a yellow solid (46 mg, 61%).

Provenance & Evidence