Sodium Hydroxide → HCID 10366304, compound

Participants

Reaction Steps

Following General Procedure E and using (2Z,4E,6E)-2,6-difluoro-3-methyl-7-(5,5,8,8-tetramethyl-3-propoxy-5,6,7,8-tetrahydro-naphthalen-2-yl)-nona-2,4,6-trienoic acid ethyl ester (Compound 26, 80 mg, 0.17 mmol), 1M NaOH (0.51 mL), and EtOH (2 mL) at 40° C. for overnight followed by flash colulmn chromatography on silica gel (10%→50% EtOAc-hexane), the title compound was obtained as a yellow solid (54 mg, 72%).

Provenance & Evidence