反应详情

温度

90 °C

In a 50 ml four neck reactor equipped with a thermometer, a dripping funnel and a refrigerant, zinc powder (2.3 g), 2-hydroxy-11-cycloeicosenone (1.4 g) and toluene (10 ml) were mixed, stirred and heated at 90° C. under nitrogen flow. A 20N sulphuric acid aqueous-solution (2.8 ml) was added thereto dropwise over 2.5 hours and the resulting mixture was stirred under heating for 30 minutes. Toluene and water were added after the reaction and the resulting solution was allowed to stand to separate into two phases. The organic phase was washed twice with water and then washed with a saturated sodium chloride aqueous solution. The solvent was removed under reduced pressure to give 1.4 g of crude product. The crude product was purified on a silica gel column chromatograph (hexane/ethyl acetate=10/1, v/v) to give 1.2 g of 10-cycloeicosenone (yield 92%).

1. stirringthe resulting mixture was stirred
2. temperatureunder heating for 30 minutes
3. customafter the reaction
4. customto separate into two phases
5. washThe organic phase was washed twice with water
6. washwashed with a saturated sodium chloride aqueous solution
7. customThe solvent was removed under reduced pressure
8. customto give 1.4 g of crude product
9. customThe crude product was purified on a silica gel column chromatograph (hexane/ethyl acetate=10/1