Fmoc-val-osu → Fmoc-Val-Lys(Mtr)

Participants

Reaction Steps

This was prepared from Fmoc-Val-OSu 7b (20.7 mmol) and Lys(Mtr) 2 (9.09 g, 1.05 equiv) as described above for 8a (15.28 g, 100%). 1H-NMR (CDCl3/CD3OD) δ 0.85 (m, 6H), 1.20 (m, 2H), 1.59 (m, 4H), 1.99 (m, 1H), 2.41 (m, 2H), 3.71 (s, 3H), 4.21 (m, 5H), 6.78 (d, 2H), 7.29 (m, 16H), 7.51 (brt, 2H), 7.71 (d, 2H). MS (FAB) 740 (MH)+, 762 (M+Na)+. HRMS Calcd: 740.3700. Found: 740.3712.

Provenance & Evidence