HCID 178513293, compound → HCID 23509940, compound

Participants

Reaction Steps

({2-(R,S)-Cyclohexyl-3-[4-(N-hydroxycarbamimidoyl)-phenyl]-propionyl}-cyclohexylmethyl-amino)-acetic acid (1.5 g, 3.38 mmol) was dissolved in acetic acid (40 ml). After addition of palladium on charcoal (10%, 100 mg), hydroxgen was bubbled in the reaction mixture at 50°C. for 8 hours. The catalyst was filtered off and washed with acetic acid. The filtrate was evaporated, the residue dissolved in water, lyophilized and purified by chromatography on Sephadex LH20 employing n-butanol (17): glacial acetic acid (1): water (2) was eluent. Pure fractions were combined. The solvent was evaporated, the residue was taken up in water, and the aqueous solution was lyophilized. Yield: 190 mg (13%), MS m/z 428.4 (M+H)+.

Provenance & Evidence