HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,6-Trimethylpyridine → HCID 178476321, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,6-Trimethylpyridine | HCID 7953 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 54143502 | HCID 54143502 | — |
| Reactant | HCID 178478814 | HCID 178478814 | — |
| Reactant | HCID 178512892 | HCID 178512892 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178476321 | HCID 178476321 | 46% |
Reaction Steps
2-(S)-{2-(S)-[3-(4-Carbamimidoyl-phenyl)-2-cyclohexyl-propionylamino]-2-cyclohexyl-acetylamino}-5-guanidino-pentanoic acid amide acid salt, less polar diastereomer, was prepared from (S)-[3-(4-carbamimidoyl-phenyl)-2-cyclohexyl-propionylamino]-cyclohexyl-acetic acid (less polar diastereomer, example 1 h), 2-(S)-amino-5-guanidino-pentanoic acid amide dihydrochloride. HATU, and collidine in dimethylformamide as described in example 3 to yield 46% of the desired product. MS m/z: 569.5 (M+H)+, 285.4 (M+2H)2+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759420B1 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-356e268924e042e7bcb9d7a5c2be6f1a |
| Source note | uspto-grants-2004_07 |