Trifluoroacetic acid → HCID 131724495, compound

Participants

Reaction Steps

{[(1-Carbamimidoyl-piperidine-4-ylmethyl)-carbamoyl]-(S)-cyclohexyl-methyl}-carbamic acid tert butyl ester hydrochloric acid salt (3.64 g crude material) was stirred with aqueous trifluoroacetic acid (90%) at room temperature for 20 hours, evaporated, dissolved in aqueous hydrochloric acid and lyophilized to yield 2.69 g (89%) of the desired product, MS m/z: 296 (M+H)+, 148 (M+2H)2+.

Provenance & Evidence