Ethylmorpholine → HCID 54486216, compound

Participants

Reaction Conditions

Reaction Steps

At 4° C., TOTU (1.59 g, 4.84 mmol) was added to a solution of 2-(3-bromo-phenyl)-3-(4-cyano-phenyl)-propionic acid (1.6 g, 4.84 mmol), 4-[(2-(S)-amino-2-cyclohexyl-acetylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester acetic acid salt (2.0 g, 4.84 mmol), and N-ethylmorpholine (1.2 ml, 9.68 mmol) in dimethylformamide (80 ml). The mixture was stirred at 22° C. for 15 hours, then evaporated in vacuo and stirred with sodium bicarbonate solution. The resulting precipitate was sucked off, washed with water, and dried in vacuo at 40° C. to give the desired product, which was used without further purification. MS m/z 665.2 (M+H+).

Provenance & Evidence