Trifluoroacetic acid → HCID 69758975, compound

Participants

Reaction Steps

A solution of (S)-{[(1-Carbamimidoyl-piperidin-4-ylmethyl)-carbamoyl]-cyclohexyl-methyl}-carbamic acid tert-butyl ester hydrochloric acid salt (20.0 g, 46.3 mmol) in trifluoroacetic acid (100 ml) was stirred for 12 hours at room temperature. The reaction mixture was evaporated and the residue was purified by Sephadex LH20 employing n-butanol (17): glacial acetic acid (1): water (2) as eluent. Pure fractions were combined to give the desired products. MS m/z: 296.2 (M+H)+.

Provenance & Evidence