4-Aminosalicylic Acid → HCID 17919667, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of para-amino-salicyclic acid (PAS) (0.47 g, 31 mmol) and Cesium carbonate (0.98 g, 3.0 mmol) in 50 ml anhydrous DMF was added elaidylmesylate (1.0 g, 2.9 mmol) and the reaction mixture was stirred at ambient temperature for 60 hours and at 35° C. for 48 hours. The reaction mixture was extracted with ether and water, and the organic phase was washed with NaHCO3(aq) and water. The solvent was evaporated off and the residue was purified on acolumn of silica gel with heptane/CH2Cl2/AcOH/MeOH (85:15:2:2) as the solvent system. Product containing fractions was repurified (70:30:2:2) and homogenous fractions were evaporated to give 0.6 g (51%) of the title compound.

Provenance & Evidence