反应详情

To a solution of 7-chloro-4-[4-[ethyl(2-hydroxyethyl)amino]1-methylbutylamino]-quinoline (hydroxychloroquine) (3.17 g, 9.4 mmol) in 30 ml dichloromethane was added elaidic acid chloride (2.82 g, 9.4 mmol) and the reaction mixturewas stirred at ambient temperature for 48 hours. A small amount of methanol was added, and the solvents were evaporated at high vacuum. The residue was repeatedly purified on a column of silica gel (first run: chloroform/methanol 9:1, second run: chloroform/methanol 95:5). Homogenous fractions were evaporated to give 1.18 g (21%) of the title compound.

1. customthe solvents were evaporated at high vacuum
2. customThe residue was repeatedly purified on a column of silica gel (first run: chloroform/methanol 9:1, second run: chloroform/methanol 95:5)
3. customHomogenous fractions were evaporated