Ethanolamine → HCID 505745, compound

HRID 1883549Notes

Reaction equation

HRID 1883549 reaction equation
CO.C(O[C:6]([C:8]1[C:9]([NH:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][N:21]=[CH:20]3)=[N:10][C:11]([S:14][CH3:15])=[N:12][CH:13]=1)=[O:7])C.[CH2:26]([CH2:28][NH2:29])[OH:27]>O>[OH:27][CH2:26][CH2:28][NH:29][C:6]([C:8]1[C:9]([NH:16][C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][N:21]=[CH:20]3)=[N:10][C:11]([S:14][CH3:15])=[N:12][CH:13]=1)=[O:7]

Participants

5

Reactant 3

HCID 700EthanolamineHCID 887MethanolHCID 11209679HCID 11209679, compound

Product 1

HCID 505745HCID 505745, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To the solution of methanol (20 ml) was added 4-(1H-5-indazolylamino)-2-methylthio-5-pyrimidinecarboxylic acid ethyl ester (1 g) prepared from preparation example 1, added ethanol amine (7 ml) at room temperature, and refluxed for 4 hr. The reaction mixture was cooled and slowly added H2O (40 ml) at 20° C. and stirred for 0.5 hr. The reaction mixture was filtered, washed with 25% aqueous methanol solution (10 ml), obtained the desired compound (0.75 g, 72%)

Workup

  1. customprepared from preparation example 1
  2. temperaturerefluxed for 4 hr
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe reaction mixture was filtered
  5. washwashed with 25% aqueous methanol solution (10 ml)

Sources & evidence

ORD record
ord-5b981ed768b8491a9a20bc91c7ba82ce
Source dataset
uspto-grants-2004_07
Patent number
US06762189B1

Reaction notes

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