Hydrochloric Acid → HCID 11596091, compound

Participants

Reaction Steps

A mixture of the olefinic ether (17) (18.27 g, 38.8 mmol) in anhydrous ethanol (350 mL), 1.0M ethereal hydrochloric acid (38.8 mL, 38.8 mmol) and 10% palladium-on-carbon catalyst was hydrogenated at 48 psi for 30 min. on a Parr shaker. It was then filtered through celite and the filter cake was washed with methanol. The combined filtrate and washings were concentrated and dried under high vacuum to obtain the title compound (18) as an off-white solid. MP 144-146° C.

Provenance & Evidence