関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Bromoacetic Acid | HCID 6227 | — |
| 反応物 | 4-Isopropylbenzoic Acid | HCID 10820 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium Sulfite | HCID 24437 | — |
| 反応物 | 3-(Chlorosulfonyl)-4-(propan-2-yl)benzoic acid | HCID 309510 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 10633915 | HCID 10633915 | 59% |
反応手順
3-Chlorosulfonyl-4-iso-propylbenzoic acid (2.62 g, 10 mmol) [made from 4-iso-propyl benzoic acid in a manner similar to that described in Procedures 7 and 8] was added slowly to a slurry of NaHCO3 (2.52 g, 30 mmol) and Na2SO3 (1.26 g 10 mmol) in water (9 ml) at 75° C. The mixture was stirred for 1 h and then treated with bromoacetic acid (2.08 g, 15 mmol) and NaOH (0.60 g, 15 mmol). The temperature was raised to 105° C. and the mixture heated at reflux for 24 h. The mixture was cooled, acidified to pH 1 and the resultant precipitate collected, washed and dried to give the title compound (1.43 g, 59%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06762192B2 |
|---|
| 出典データセット | uspto-grants-2004_07 |
|---|
| ORD ID | ord-4387bcb48f9b42cdb2901049dec1390b |
|---|
| 出典メモ | uspto-grants-2004_07 |
|---|
