HuagongsheHuagongshe Chemistry Print Report · For research reference only
Furfural → HCID 22241190, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Furfural | HCID 7362 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(5-hydroxy-2,6-dioxo-3-piperidinyl)- | HCID 9922018 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 22241190 | HCID 22241190 | — |
Reaction Steps
A solution of 3-(4-amino-1,3-dioxoisoindolin-2-yl)-5-hydroxypiperidine-2,6-dione (0.82 g, 3.0 mmol) and 2-furaldehyde (0.34 g, 3.5 mmol) in acetic acid (10 mL) is heated at reflux for 4 hours. To the mixture is added sodium borohydride (130 mg, 3.5 mmol) at room temperature and this mixture is maintained for 18 hours. The mixture is worked up to give 3-(4-fur-2-ylmethylamino-1,3-dioxoisoindolin-2-yl)-5-hydroxypiperidine-2,6-dione which is further purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06762195B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-8e8c8550407d4b74897005853970de26 |
| Source note | uspto-grants-2004_07 |